Blind Athlete Shawn Cheshire Aims to set Guinness World Record for Grand Canyon Rim to Rim to Rim Crossing.

Multi-sport Paralympic Athlete will attack the feat on October 7, 2018.

FT. LAUDERDALE, FLORIDA, USA, August 1, 2018 / — —— Paralympic cyclist and blind multi-sport athlete Shawn Cheshire is a fearless woman. The roundtrip trail crossing of the Grand Canyon (Rim to Rim to Rim) is not a challenge for the faint of heart and yet Shawn doesn’t use words like “attempt.” She states, “I’m not going to attempt this. I’m going to crush it.” Her conviction leads one to believe that no other option is possible.

She’ll be doing the Grand Canyon Rim to Rim to Rim on Sunday, October 7, 2018. The Guinness Book of World Records has been contacted so that the record for a blind woman making this journey can be chronicled and established.

Because she is blind, Shawn will have two guides for this journey. One guide will lead Shawn wearing a bell for her to follow and the second guide will trail her giving verbal feedback. She will also use a rigid hiking cane.

The Grand Canyon is considered one of seven natural wonders of the world. It is 18 miles wide and attains a depth of approximately 6,000 feet. Hiking rim-to-rim (21 miles) is considered one of America's most dangerous hikes, causing 350 heat-related rescues in the park every year. Shawn is doing Rim to Rim to Rim (roundtrip) making the journey 42 miles in total.

This journey contains other perils. Approximately 5 hikers on average die every year. The challenge is accentuated by hellish-heat combined with 20,000 feet of vertical states that, “The dark grey schist at lower elevations absorbs and radiates heat like a cast-iron frying pan, so when thermometers read 110°F in the shade, hikers endure 130°F ground temps on the trail.” Flash floods can also occur anytime of the year, the National Parks Service reports that hikers have died from floods generated by thunderstorms as far as 25 miles away.

No stranger to the Grand Canyon, Shawn Cheshire hiked a much shorter version of the trails earlier this year. She regretfully never saw the Grand Canyon when she had her sight. Her other heightened senses plus the accomplishment will no doubt bring about a tremendous appreciation of this beautiful natural resource.

Shawn endures a rigorous training routine and is a successful cyclist with multiple national titles. Overcoming obstacles has become somewhat routine for Shawn. She is suing the United States Olympic Committee in a California federal court after sustaining a concussion at a mandatory training camp because the USOC prohibited her from using her seeing eye dog.

Shawn participated in the Paralympic Games in 2016 and is working hard to qualify for the Paralympic Games in Tokyo in 2020.

About Shawn Cheshire

Shawn Cheshire served in the US Army as a helicopter armament systems mechanic. Following her years in the service, Shawn became an EMT-Paramedic fueling her passion to care for others. In 2009, while working on an ambulance, she sustained a traumatic brain injury which resulted in total loss of vision. Shawn confronted her blindness and ignited her competitive spirit through experiencing and competing in parasports. For the last three years, Shawn has raced with the US National Paralympic Cycling Team in 20 domestic and 20 international races, including representing the USA at the Paralympic Games in Rio 2016. Shawn is an 11 time US National Champion.

Shawn doesn’t limit herself to just cycling. She snowboards, cross country and downhill skis, paddle boards, hikes and runs.



For more information, contact: Mike Mena at: 310-913-0625 or
# # #

Mike Mena
email us here
Ileana International

Source: EIN Presswire

WorkBootCritic – Your Go-To Website for Work Shoes Reviews

BOSTON, MASSACHUSSETS, UNITED STATES, August 1, 2018 / — As the first half of 2018 ends, it is time once again for Work Boot Critic to look back at its accomplishments and evaluate what it brings new to the table. Because it is one of the few websites in the niche that covers various professional footwear related topics, its articles are specifically targeted towards a diverse pool of conversation topics.

What the Website Offers

Work Boot Critic is one of the most expansive resources for professional footwear information for a reason. Due to its wide array of articles, you can rest assured that you will find almost anything you need. Here are the four main things offered by the website at the moment, as well as in the future.

• Work boot maintenance tips. The footwear you take with you on the job is constantly placed under a lot of strain due to the intensive nature of your daily activities. Fortunately, Work Boot Critic offers an all-embracing repair guide, as well as other accessible maintenance tips that will extend the lifespan of your shoes. With this additional resource on how to repair your boots, you will be able to make the most out of a pair of shoes before moving onto the next.

• DIY recommendations. Even the most basic pair of work boots can be improved with the help of simple DIY items. The market offers plenty of waterproofing creams that can transform any regular footwear into something that can withstand more extreme weather conditions. For anyone looking to try this DIY at home, WBC offers more info on the best boot waterproofing spray you can find on the market. What is more, even boots who are already technically waterproof can benefit from such techniques, as it increases their resistance.

• Footwear reviews for any situation. Depending on the nature of your occupation, you will require various layers of protection as far as your work boots are concerned. The website offers extensive reviews of insulated work boots that can handle even the harshest cold of winter, as well as various other types of boots to fit just about any other situation you might be faced with on the job.

• A community of like-minded professionals. The format adopted by the website promotes discussions among users. Thus, not only are they able to get valuable recommendations from the contributing authors, but also ask around and debate topics with their peers. This creates a tight-knit community of like-minded professionals that keeps growing and improving every day.

About Work Boot Critic

The team behind Work Boot Critic started out with one ambitious goal in mind, namely to bring professional laborers in physically intensive jobs the best footwear advice available. The type of shoes worn on the job makes all the difference in the world in terms of safety and comfort on site, and no one knows that better than them.

For this reason, over the course of the time the website managed to accrue a wide selection of reviews and recommendations to fit the requirements of every single field. Thus, whether you work in construction, landscaping, or waste management, Work Boot Critic has you covered. With a lot of hard work, it became one of the best resources in the field.

Vincent West

email us here

Source: EIN Presswire's Most Popular Articles

LOS ANGELES, CA, US, August 1, 2018 / — Now that the second half of 2018 is well into its rights, it’s time once again to take a look at what has achieved so far. Over the course of the past seven months, the website has produced new high-quality articles, as well as updated old ones to keep the readers informed on the important news in the field.

Top 3 Articles in 2018

As months passed by and the current year progressed, kept uploading informative content and revamping its older articles. This naturally drew in a lot of fresh views and clicks, and now the numbers are finally in. Here is a brief overview of the website’s top three most popular posts so far.

• Top 10 Indoor Cycling Bikes in the Market. It’s no secret that the spinning industry has many state of the art fitness machines to offer to enthusiasts. Taking an informed pick can be quite challenging. Therefore, the first article to draw major attention in 2018 is the one dealing with the market’s top ten indoor cycling bikes. Check this for a spinning bike comparison organized under the form of an informative chart detailing essential information such as ratings, pricing, weight, and other aspects. It is the perfect piece to read if you are in the market for a new spinner and don’t know where to start.

• Sunny Health & Fitness Indoor Cycle Trainer. Speaking of spin bikes comparisons and reviews, ExerciseBikesExpert is known for offering detailed individual articles about specific machines as well. One of the most popular ones on the market right now is the Sunny Health & Fitness Belt Drive Indoor Bicycle, as it offers customers a great value for money. If you are interested in making a purchase, you can always read more about the Sunny Health & Fitness SF B1002 on the website and get all the necessary details before spending your hard earned money.

• Chain-Driven Spin Bikes or Belt-Driven Spin Bikes? Which Is Better? If you’ve ever been wondering about what the main differences between classic chain drives and innovative belt drives are, then this is certainly the article for you. It provides further reading on the belt drive spin bike in comparison to the older technology, outlining benefits and drawbacks along the way. In this way, you will know whether or not upgrading your equipment is something that you need to do for your home gym.

About ExerciseBikesExpert

The main goal of has always been to keep fitness and healthy living enthusiasts in the loop. Kristin, the website’s founder, is a firm believer in the powers of a clean lifestyle that is based on regular exercise, an organic diet, and an overall positive outlook on life. This is reflected in the pieces that are published regularly on there.

Therefore, the page is not only a resource of detailed spinning information, but also offers a wide array of articles concerning other topics that pertain to this field of interest. Over the years, it managed to create a tight-knit community of like-minded individuals, and it will carry on doing so in the future.

Luke Mitchell

email us here

Source: EIN Presswire

RJ Models finished the installation of Latest Global Cruise Terminal and Luxurious AIDA Cruises Models in Dubai.

Model Making Company, RJ Models

Model Making Company, RJ Models

Model Making Company, RJ Models

RJ Models and 3DR Models have been appointed to be the model maker of Dubai Harbor and Dubai Harbor Cruise Terminal Project.

It is an honor for RJ Models and 3DR Models to be involved in this project and we are grateful to our clients for their complete trust.”

— Ray Cheung

SHEN ZHEN, GUANG DONG, CHINA, August 1, 2018 / — Dubai’s government officially announced the plan to develop a new “Dubai Harbor” recently.

Dubai’s President Sheikh Mohammed Bin Rashid Al Maktoum attended the exhibition of the Dubai Harbor development plan event to view the 1:400 and 1:150 architectural models.

Founder and director of RJ Models, Mr. Ray Cheung said, “It is an honor for RJ Models and 3DR Models to be involved in this project and we are grateful to our clients for their complete trust. We have also fully committed to the project and lived up to our clients’ expectations.”

The new Dubai Harbor will house a 1,400-berth marina, a 135-meters tall lighthouse, a cruise port and terminal with the capacity to handle 6000 tourists and a 150,000-meters long port.

After four weeks’ of hard work and the close cooperation between the frontline engineers and the production team in Shenzhen, China, RJ Models provides stunning architectural models to clients and viewers, including a model for Dubai Harbor in a scale of 1:400 and a Dubai Harbor Cruise Terminal in scale of 1:150.

To ensure the models’ vividness, RJ Models defined and fabricated every component with accuracy, dedicated more than ten arch¬¬itectural model makers in Dubai.

The final masterpieces gained appreciation and praise from clients and audiences. “It’s the best cruise ship model I have ever seen!” said the CEO of Carnival Holdings & PLC.

About RJ Models

For 23 years now, RJ Models has grown to be a leader in world-class architectural model making company.

It offers a range of top quality architectural model making services with a tight deadline for competitive rates. With RJ Models, clients can enjoy our all team support on you.

At every stage, RJ Models aims to provide the top quality architectural models to boost our client’s business to all architecture in the world.

For more information:

Contact person: Ray Cheung
Contact email:
Tel no: (00852) 2557-0201

About 3DR Models

Founded in 1989 3DR Models is a most dynamic & A-list model maker which the whole world is familiar with. 3DR's work covers residential development; government buildings; university buildings; airports; public & private institutions; banking and financial institutions; healthcare facilities; recreational & sports facilities, etc.

Besides, other supporting facilities such as model transportation; model relocation; model installation; model modification warehouse for the model are available. No matter where you are, 3DR brings the world to you. No matter what time it is, 3DR is always at your service.

For more information:

Contact person: Dani A. Bterrani
Contact email:
Tel no: (+971) 43474898

Ray Cheung
RJ Models
(+852) 2557 0201
email us here

Source: EIN Presswire

CEE Real Estate Group providing opportunity in CEE growing market

Lab - nice village nearby Bratislava where investors wanted


functionalist building in Bratislava

Central & Eastern Europe experiencing investment boom for past years and still blossoming.

BRATISLAVA, SLOVAKIA, August 1, 2018 / — In words of investments, Central & Eastern Europe has experienced the growth in investments to the real estate, mainly in new commercial facilities. Those were popping up across Czech Republic, Romania, Slovakia, Hungary…

Last year, in 2017 the transactions connected with investing into the commercial real estate market broke the record, with Poland being the leader.

In CEE Real Estate Group, focus on commercial real estate is one of the areas where the group is operating. With intention to provide investors with high-quality and peerless ROI, the company is operating on the market of Central & Eastern European market with intention to provide valuable investments for investors worldwide.

Although the company's interest and innovative way of searching for investors worldwide, the company is recently becoming interesting for investors from Middle East, Asia and North America – which are according to analytics also the investors who are having the largest share in terms of market activity. So far, the company managed to provide its investors with 30% ROI approximately for more than 15 buy-fix-sell projects.

CEE Real Estate Group's experienced research team and network of architects, construction companies and real estate agents can offer any investor all sizes of buy-fix-sell projects in the CEE region.

The company target to get a minimum of 25% ROI per buy-fix-sell project, working on a no cure – no pay basses, what means they only get a performance fee based on results.

CEE real estate group is the first real estate asset management company which offers buy-fix-sell projects to be order fully online for any investor anywhere in the world, no physical appearance needed what makes them innovative and approachable for anyone.

Follow the 3 easy steps online in member area, Step 1: fill in your details, Step 2: down & upload documents, Step 3: payment details and track your investment.

"Our research team will then start looking for a tailor-made Buy-Fix-Sell project based on your budget, as our legal team will set up a segregated secure account in your name by the state notary office or bank in Bratislava." described the representative of the company.

The state notary or bank will hold your funds to buy the property, provide for the renovation and for any other cost involved with the buy-fix-sell project.

The state notary will provide the title deed on your own name and they or the bank collect the funds to your segregated secure account after the buy-fix-sell project is completed and sold with a profit.

Ondrej Cirbus
CEE Real Estate Group
+421 233056141
email us here

Company video presentation

Source: EIN Presswire

Harvey Law Group announces Strategic Partnership with Range Developments in SEA in Six Senses St. Kitts & Nevis

Mr. Jean-François Harvey Global Managing Partner of Harvey Law Group (left) and Mr. Bastien Trelcat, Managing Partner Southeast Asia (right) officially announced the strategic partnership with Range Developments in Southeast Asia in May 2018

Harvey Law Group announces Strategic Partnership with Range Developments in Southeast Asia for the newly launch Six Senses St. Kitts Resort and Spa.

HLG is collaborating again with Range Developments,the government of St Kitts & Nevis for the Six Senses project,as the exclusive service provider for SEA of 100 shares coming with a financing option”

— Bastien Trelcat, managing partner, Harvey Law Group, SEA

SINGAPORE, SINGAPORE, August 1, 2018 / — Harvey Law Group announces Strategic Partnership with Range Developments in Southeast Asia for the newly launch Six Senses St. Kitts Resort and Spa. Steeped in legendary seafaring history dating back hundreds of years, the Eastern Caribbean island of St. Kitts & Nevis is the newest exotic destination for Six Senses Hotels Resorts Spas.

The resort will be set on the site of a former sugar cane plantation with gentle hills rolling down to a long stretch of sandy beach fronting the Caribbean Sea. All of the projected 70 pool villas and The Retreat will enjoy sea views and an unspoiled environment that gives the glorious feeling of being isolated from civilization; a place where guests can reconnect with themselves, their families and loved ones and nature.

In true Six Senses style, every aspect of the 70 villas all with private plunge pools are true to the Six Senses commitment to the environment, using sustainable and repurposed materials juxtaposed with contemporary comforts.

Overlooking the resort’s nature reserve, Six Senses St. Kitts will feature a menu of Six Senses specialty treatments as well as Caribbean healing traditions and rejuvenation journeys, Six Senses Integrative Wellness, detox, yoga and workshops.

To the south of the resort is Sandy Point Town, the second largest town on the island. Sandy point is the entrance way to Brimstone Hill, a UNESCO World Heritage Site and just one of the many fascinating excursions that await history enthusiasts. Located on the western side of the island, the site for Six Senses St. Kitts is approximately a 30-minute drive along the scenic coast road from the capital Basseterre and the International Airport (SKB). The airport is served by direct flights from the United States, Canada and the United Kingdom, with connecting and charter flights from Europe and regional services from several Caribbean nations.

Six Senses St. Kitts is a project by Range Developments, which specializes in developing luxury Caribbean resorts, together with design creativity, management and marketing by Six Senses Hotels Resorts Spas. The resort is scheduled to be completed over three years.

On announcing the project, Six Senses President Bernhard Bohnenberger said, “We are thrilled to add St. Kitts to the Six Senses portfolio of resorts in incredible settings. And working in partnership with Range Developments, who have exceptional expertise and experience in the Caribbean, Six Senses St. Kitts will be a remarkable resort.” Six Senses St. Kitts will be the 16th hotel of the Six Senses Group which is now present in 11 different countries.

“We are excited to welcome Six Senses to St. Kitts and delighted to announce it from the capital of the fastest growing economy in Asia, Beijing,” said Mohammed Asaria, founder of Range Developments. “Six Senses was recently voted the world’s best hotel brand by Travel +Leisure magazine and we look forward to working together on this exciting project.”

Mr. Bastien Trelcat, Managing Partner of the leading investment immigration firm Harvey Law Group for Southeast Asia added “Harvey Law Group is honored to collaborate one more time with Range Developments and the Government of St. Kitts & Nevis for the Six Senses project as the exclusive service provider for Southeast Asia of 100 shares coming with a financing option. St. Kitts boasts the longest established Citizenship by Investment program in the world presenting opportunities to obtain a well-recognized passport for you and your family.”

Investors who invest USD 220,000, with financing available over 2 years, in this project can attain citizenship for their immediate family and a number of eligible dependents. Investors will receive St. Kitts & Nevis passports, within 90 to 120 days of filing an application, and are also free from personal income, capital gains, gift, wealth and inheritance taxes.

St. Kitts & Nevis citizens may travel visa-free to over 140 countries, including the United Kingdom, Schengen European countries and most British Commonwealth countries. Dual citizenship is permitted and opens to all nationalities, without any requirement to notify the applicant’s home country.

Harvey Law Group (HLG), one of Asia’s leading legal firms focusing on investment immigration and mobility, announced that one of its portfolio companies has acquired nearly 20% of the inventory in the newly launched Six Senses St. Kitts being developed by Range Developments (Range) under the St. Kitts & Nevis Citizenship-by-Investment program. The agreement between Range and Harvey Law Group was signed on May 8, 2018 securing access to units in the development for HLG’s well-established clientele in Asia-Pacific.

About Harvey Law Group
Harvey Law Group is a multinational law firm dealing with corporate law and investment immigration with a worldwide reputation for representing high-profile clients and corporations, with over 19 offices worldwide. As one of the well-known HNWI law firms, HLG offers the most comprehensive residency and citizenship programs available to date. Harvey Law Group was awarded the Immigration Law Firm of The Year at the Annual Macallan ALB Hong Kong Law Awards in 2014 and 2017. It is notable that Harvey Law Group has been offering Business Immigration Services since 1992 and therefore making it one of the oldest firm in this highly specialized field.

For further inquiries on exclusive financing option or investment immigration program opportunities, please contact HLG Worldwide Managing Partner, Mr. Jean-François Harvey ( and HLG Managing Partner, Bastien Trelcat ( )

Call +6626701848 or visit or FB:

Media Contact:

Jim James| Josiah Tan
EASTWEST PR for Harvey Law Group
(65) 6222 0306
email us here

Source: EIN Presswire

Himalaya Capital Exchange & Symphony ICOs kick off Europe Roadshow in London, Paris, Zurich, Berlin Aug 2018

Himalaya Capital Exchange revolutionising the securities industry

Himalaya Capital Exchange – The Next Generation Borderless Stock Exchange that runs on Smart Contracts

Unstoppable Capital Europe Roadshow August 2018

HCX & Symphony ICOs Roadshow. Don’t miss the free token drop!

Himalaya Capital Exchange (HCX) kicks off Token Storm Europe Roadshow – London, Paris, Zurich, Berlin August 2018 with Symphony ICO

Capital flows along the path of least resistance, like water. HCX is creating a new paradigm for capital markets, democratising and making the process frictionless, removing intermediaries and fees.”

— John Puttick, CSO

LONDON , LONDON, UNITED KINGDOM, August 1, 2018 / — Himalaya Capital Exchange (HCX) and Symphony are revolutionary Blockchain projects that are poised to occupy pioneering positions in the crypto economy, and the ICOs are hosting meetings and presentations in Europe during 13 August to 20 August, to meet crypto enthusiasts, crypto funds, influencers, asset management and capital markets professionals across the European & MENA hubs:
London – 13 August 6-9pm – Rise London, 41 Luke Street
Paris – 16 August 12-5pm – Sofitel Arc Du Triomphe
Zurich – 17 August 12-6pm – St Gotthard Hotel, Bahnofstrasse
Berlin – 20 August 6-9pm – Impact hub, Friedrichestrasse
Dubai – 27 August 9-6pm – Ramada Plaza Jumeirah 

RSVP to events here 
To get an invitation to private presentations, please email

About Symphony Protocol:
Symphony Protocol is a next-generation, blockchain based protocol to empower a data-driven economy.  It is an infrastructure layer project, which will form the basis of an ecosystem of decentralized applications that focus on data intelligence, and creating an asset class for personal data.  Symphony token sale is in the cornerstone & private sale stage.  Currently, Symphony is backed by BMG Fund and others.

About HCX (Himalaya Capital Exchange): A Security Token Issuance Platform

Himalaya Capital Exchange is a project aimed at creating a tokenised platform for Initial Public Offerings (IPOs) on a global, borderless, stock exchange. The Platform As a Service eco-system would offer an alternative to investment banks that are currently mandated to lead-manage IPOs, and give corporates, governments, and other entities raising public capital a less costly, and more democratic option with instant access to global investors. We are giving entrepreneurs everywhere the chance to create their own shares and bonds, and raise money within minutes from across the world frictionlessly. The platform would run on smart contract algorithms and at a later point make use of Machine Learning and AI in matching and creating a marketplace. This will be a first of its kind securities marketplace governed by token holders. Currently HCX is backed by John Puttick (Chairman of GBST), Arun Sharma (Vice Chancellor at Queensland University), Leanne Kemp (CEO of Everledger), Ghanshyam Dass (ex Director of NASDAQ & Board Member of KPMG), Mario Pazos (Pazos Law, USA) and others. Currently in private token sale before launching the public pre sale of tokens in Oct18.

White Paper:

Arifa Khan, CEO, is a crypto pioneer who authored the first ever Concept Paper on decentralising capital markets (June 2017) before security tokens were invented. She later architected a platform ecosystem for capital markets participants in her revolutionary white paper published and presented to Nick Szabo on 25 May 2018. She founded HCX in 2017- a decentralized stock exchange that runs trustlessly on smart contracts – to bring that vision to reality and travelled the world for a full year to educate non crypto savvy people in remote corners on the benefits of self-issuing security tokens. HCX is the first-of-its-kind disruption which automates the role of investment banks, and empowers entrepreneurs around the world to issue their own security tokens. Arifa Khan is India Partner of the Ethereum Foundation and leads Ethereum’s community development efforts in India & Middle East. She has an MBA from Wharton School of Business, and a B.Tech from IIT Madras. She is a sought after international public speaker and has given keynote speeches at several global forums such as Crypto Investor Show London, Bengaluru Tech Summit, D10e Davos, Ethereum India Summit, Blockchain UA Kiev, Blockchain & ICO Summit Istanbul, Hybrid Block Macau Summit, Himalaya Crypto Summit 2018. She is listed among Top 100 fintech influencers by Lattice80.

Token Storm, part of Zero Field Labs – a Blockchain play – aims to create the foundations of a new token economy ecosystem which will bring together the world’s leading Blockchain startups along with key players in the crypto landscape spanning investors, innovators, developers, and crypto enthusiasts.

Token Storm provides global ICOs a platform to build community outreach in a global roadshow to create opportunities for education, on-boarding of users, and collaboration in the Blockchain ecosystem.

“Given the unprecedented growth of the Blockchain industry, Token Storm provides a ready marketing platform for ICOs, and for anyone to participate in the exciting crypto economy, earn free token airdrops, meet founders face to face, ask questions and learn about disruptions coming their way. We welcome ICOs to leverage our immense network and outreach and economies of scale in community building” said Arifa Khan, who is leading Token Storm Global Roadshow 2018. Previous ICO showcases have attracted thousands of participants and have featured the world’s most passionate crypto enthusiasts and prominent experts, and covered more than 10 countries in megapolis such as Singapore, Hong Kong, Seoul, Shanghai, London, Dubai, Istanbul, Kiev, Paris, Chennai.

The Asia Tour Sep 2018 kicks off with Bangkok 29 Aug, visits Kualalumpur, Shenzhen, HongKong 5 Sep, Shanghai 12 Sep, Seoul 14 Sep, Tokyo 16 Sep, Hanoi, Ho Chi Minh City, Singapore 20 Sep, and ends in London 26 Sep. In each city, Token Storm will facilitate ICOs engaging with Blockchain and Crypto community, and potential investors.

"We are delighted to participate in Token Storm events. With their global reach and network, Blockchain expertise and track record, Token Storm is the ideal venue for global disruptive ICOs to connect with investors and the public alike, to showcase their venture across the world, and to build a user community. Arifa Khan has been a
pioneering eco system builder since blockchain’s early days. Her network and access in the crypto economy is phenomenal and one can only aspire to experience the richness of insights and the connections Token Storm have with the crypto innovators across the globe” says Mario Pazos, Blockchain Angel Investor and an early backer of HCX ICO.

Token Storm meetups at global financial hubs of the world represent a unique opportunity for tech enthusiasts, investors, developers and the local community to participate in Blockchain projects and witness first-hand the ICOs bringing a paradigm shift to various industries.

Arifa Khan
Himalaya Labs Pvt Ltd
email us here

Join HCX ICO Global Roadshow – Token Storm visits 15 countries in Europe & Asia in 30 days

Source: EIN Presswire

ENPICOM Releases Immune Repertoire Sequencing Analysis Platform to Personalize Immunotherapies

ImmunoGenomiX GUI

IGX graphical user interface

immuosequencing benchmarking

IGX benchmarking results

Dutch bioinformatics software engineering company finalizes development and releases the first version of their ImmunoGenomiX platform

These results are very comforting, as highly accurate clonality analysis is the stepping stone towards successful application of this technology in the clinic at later stage”

— Dr. Nicola Bonzanni, CSO

'S-HERTOGENBOSCH, NETHERLANDS, August 1, 2018 / — Today ENPICOM announced that they have finalized development and released the first version of their ImmunoGenomiX (IGX) platform to support the development, patient stratification and treatment monitoring of immunotherapies.

The adaptive immune system, also known as the acquired immune system, is a subsystem of the overall immune system that is composed of T and B lymphocytes, which eliminate pathogens or prevent their growth. Moreover, the clinical relevance of T cells in the control of different human cancers and autoimmune diseases is beyond doubt. Immunotherapies that boost the ability of T cells to destroy cancer cells have proven therapeutic efficacy in a variety of human malignancies.

ENPICOM develops a T cell and B cell receptor (TCR/BCR) repertoire immunosequencing data analysis solution. This IGX platform will be modularly expanded to become a comprehensive end-to-end immunosequencing data analysis platform designed to analyze, monitor, and compare the immune repertoires in the context of immunotherapy development and at all stages of treatment and disease over time. Starting from high-throughput sequencing data, it will deliver an easy-to-read report depending on the specific application, be it research, diagnosis, patient stratification, or treatment monitoring. The IGX platform will allow customers to use their own sample preparation protocols and the next-generation sequencing technology of choice. It requires no programming skills as the interface is intuitive and flexible.

The first version is available as of today and consists of the base module, IGX Explore, to analyze TCR repertoires from raw sequencing data, report back the number of individual TCR clones and interactively visualize them in a user-friendly way. With IGX Explore (TCR) immunotherapy companies can boost their target discovery, research and drug development processes. In case they need TCR repertoire analysis for a specific application or results visualized in a different way, ENPICOM can custom-build it.

Using a recently published and independent benchmark, ENPICOM showed that IGX Explore offers superior accuracy. The independent benchmark was published in a recent paper by Afzal et al., in which the authors benchmarked ten state-of-the-art TCR repertoire analysis tools. More information about this benchmark study can be found at the company’s website.

Dr. Nicola Bonzanni, Chief Scientific Officer, explains: “An important step in repertoire analysis is the correction of sequencing errors. If sequencing errors were left uncorrected, the richness of a sample would be vastly overestimated; correcting too many errors would lead to under-estimating richness. A critical challenge in immune repertoire analysis is to correct the sequencing errors in the data without losing repertoire-specific information in the process. IGX Explore uses an Adaptive Error Correction algorithm that learns sample-specific mutation rates from the data. By using sample-specific error estimations, erroneous sequences can then be corrected to provide accurate clone sequences, sizes, and frequencies” and adds “These results are very comforting, as highly accurate clonality analysis is the stepping stone towards successful application of this technology in the clinic at later stage”.

Jos Lunenberg
email us here

Source: EIN Presswire